WEBINAR:

Predictive DILI models

Human Liver Microphysiological System for Studying Acute and Chronic Drug-Induced Liver Toxicity

In this webinar, CN Bio Senior Scientist Dr. Ovidiu Novac will discuss how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

Speaker Information:
Dr-Ovidiu-Novac
Dr Ovidiu Novac

Senior Scientist
CN Bio

Watch this webinar to learn:

  • Discover how the liver MPS can be used to detect mild through to severe DILI toxicants
  • Understand how MPS can be used to generate mechanistic signatures of hepatotoxicity
  • Enable your scientists to reduce drug attrition in the early phases of clinical trials

With safety concerns being the major cause for failures in phases 1/2 clinical trials, it’s essential to develop more predictive models within preclinical drug discovery to improve data translatability.

In this webinar, CN Bio Senior Scientist Dr. Ovidiu Novac will discuss how a human liver microphysiological system (MPS), or Liver-on-a-chip, can be used to understand the causality and mechanistic aspects of drug-induced liver injury (DILI).

Ovidiu will discuss how his team validated the MPS using a broad set of mild to severely hepatotoxic compounds and how the MPS delivered novel insights not previously seen in vitro.

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