Go with the Flow

Application of Microfluidic 3D Liver Chip Models To Genotoxicity Testing

This webinar details the current challenges in the field of integrating microphysiological systems with classic genetic toxicology and describes advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.

Speaker Information:
Dr Renato Cardoso

Scientific Director of Genetic Toxicology
Charles River Laboratories (Montreal - Canada)

Watch this webinar to learn:

  • Issues of current pre-clinical in vitro drug metabolism and genotoxicity tools and their low predictive power
  • Obstacles to integrating novel microphysiological systems with classic genetic toxicology
  • Recent advancements to successfully overcome these challenges

Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells.

The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials. 

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