This webinar details the current challenges in the field of integrating microphysiological systems with classic genetic toxicology and describes advancements made in the Genetic Toxicology Department-Charles River Montreal to successfully tackle these endeavors.
Scientific Director of Genetic Toxicology
Charles River Laboratories (Montreal - Canada)
Watch this webinar to learn:
Current in vitro pre-clinical genetic toxicology tools used to determine drug metabolism and genotoxicity consist of a metabolic activation system (induced rat S9 mix) and single cells.
The low concordance between rat and human metabolism is a potential cause for the low predictive power of rat models for human liver toxicity in clinical trials.
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