Fighting Toxic Chemicals

Evaluating the Safety of Cobinamide as a Neutralizing Agent

This webinar outlines how Professor Boss' lab used CN Bio’s Toxicity Testing Services to investigate the hepatotoxicity of two cobinamide formulations. Professor Boss discusses the results of the study, and how the work informed which formulations of cobinamide could be safe for humans.

Speaker Information:
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Professor Gerard R Boss, MD

Distinguished Professor of Medicine, UCSD

Watch this webinar to learn:

  • Discover more about cross-species hepatotoxicity variability
  • Learn about drug sensitivity in dogs versus other test species
  • Understand the importance of human-relevant drug evaluation

Professor Gerard Boss' lab at the University of California San Diego is developing the vitamin B12 analog cobinamide as an antidote against toxic chemicals. Previous research established that cobinamide is well tolerated by mice, rats, rabbits and pigs, but caused hepatotoxicity in dogs. To gain insight into its potential effect in humans, Professor Boss and colleagues wanted to test it against an in vitro primary hepatocyte model.

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